⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147401 | 0.84 | HRH3 (0.32) | — | |
| SCHEMBL22958642 | 0.69 | — | — | |
| SCHEMBL22049982 | 0.68 | — | — | |
| SCHEMBL21776252 | 0.67 | OPRM1 (0.31) | — | |
| SCHEMBL22108163 | 0.66 | OPRM1 (0.32) | — | |
| SCHEMBL21776052 | 0.66 | — | — | |
| SCHEMBL11573468 | 0.65 | — | — | |
| SCHEMBL19630484 | 0.65 | KDM4E (0.38) | — | |
| SCHEMBL31249931 | 0.64 | HRH3 (0.33) | — | |
| SCHEMBL31249923 | 0.64 | HRH3 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10441581-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2019-10-15 | — | — | US | disclosed |
| US-20180133207-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |