SCHEMBL2014804

SCHEMBL2014804

CN(C(=O)c1cncc2ccccc12)C(CCNC(=O)c1cccn1C)Cc1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 2/20 0.58
HCRTR2 O43614 2/20 0.58
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
PADI4 Q9UM07 3/20 0.40
CCR1 P32246 1/20 0.38
HDAC6 Q9UBN7 2/20 0.36
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC5 Q9UQL6 1/20 0.36
ALDH1A1 P00352 1/20 0.35
HRH3 Q9Y5N1 2/20 0.35
MEN1 O00255 1/20 0.34
UBE2N P61088 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2011939 0.89 HCRTR1 (0.58) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2010990 0.89 HCRTR1 (0.58) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2015340 0.85 HCRTR1 (0.57) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2013656 0.84 HCRTR1 (0.66) HCRTR1HCRTR2CCR1ALDH1A1MEN1
SCHEMBL2052571 0.84 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL2017894 0.84 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL2012147 0.83 HCRTR1 (0.61) HCRTR1HCRTR2NPC1RAB9AHDAC6
SCHEMBL2051271 0.83 HCRTR1 (0.61) HCRTR1HCRTR2NPC1RAB9AHDAC6
SCHEMBL2011717 0.83 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2013176 0.83 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO claimed
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO disclosed