Sugi Predict

Sugi Predict / Compounds / SCHEMBL20148045

SCHEMBL20148045

SCHEMBL20148045

CC(C)N1CC(Nc2ccc(F)cc2)C1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ GFER P55789 4/20 0.40
▸ HRH3 Q9Y5N1 1/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ MAPK1 P28482 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ GAA P10253 2/20 0.37
▸ POLB P06746 2/20 0.37
▸ ALDH1A1 P00352 1/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.37
▸ MLNR O43193 2/20 0.37
▸ CYP3A4 P08684 2/20 0.37
▸ MAPT P10636 1/20 0.36
▸ RECQL P46063 1/20 0.36
▸ SSTR5 P35346 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20147465 0.84 MAPT (0.37) KMT2AGAAPOLBALDH1A1CYP3A4
SCHEMBL11253819 0.81 ALDH1A1 (0.45) GFERHRH3KMT2AALDH1A1MAPT
SCHEMBL20069457 0.79 POLB (0.44) GFERHRH3KMT2AMAPK1HSD17B10
SCHEMBL24188503 0.79 KMT2A (0.41) HRH3KMT2AGAAPOLBCYP3A4
Hydrochloric Acid SCHEMBL11241377 0.79 ALDH1A1 (0.43) GFERHRH3KMT2AALDH1A1MAPT
Hydrochloric Acid SCHEMBL11241402 0.79 ALDH1A1 (0.43) GFERHRH3KMT2AALDH1A1MAPT
SCHEMBL9900566 0.77 OPRM1 (0.44) KMT2AMAPK1GAAALDH1A1NPSR1
SCHEMBL539395 0.72 DDB1 (0.46) MAPK1HSD17B10GAAPOLBMAPT
SCHEMBL25004304 0.72 HRH3 (0.44) HRH3MAPTRECQL
SCHEMBL3327503 0.72 HRH3 (0.54) GFERHRH3KMT2AALDH1A1MLNR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023198597-A1 RIFABUTIN ANALOGS FOR THE TREATMENT OF DISEASE BioVersys AG (CH) 2023-10-19 — — WO disclosed
WO-2023118319-A1 RIFABUTIN ANALOGS FOR THE TREATMENT OF DISEASE BioVersys AG (CH) 2023-06-29 — — WO disclosed
US-10881652-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2021-01-05 — — US disclosed
US-10441581-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2019-10-15 — — US disclosed
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-31 — — US disclosed
US-20180133207-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10881652-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 GFER 4412/4885HRH3 1000/4885KMT2A 1112/4885
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 GFER 4412/4885HRH3 1000/4885KMT2A 1112/4885
US-10441581-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 GFER 4412/4885HRH3 1000/4885KMT2A 1112/4885
US-20180133207-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 GFER 4412/4885HRH3 1000/4885KMT2A 1112/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.