Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | FGF23 | Q9GZV9 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12724869 | 1.00 | MAPT (0.62) | MAPTSMN1; SMN2ALOX12FGF23CSNK1D | |
| SCHEMBL13548653 | 0.84 | PDE2A (0.42) | MAPTSMN1; SMN2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8943045 | 0.80 | MAPT (0.74) | MAPTSMN1; SMN2ALOX12FGF23ALDH1A1 | |
| SCHEMBL8943048 | 0.80 | MAPT (0.74) | MAPTSMN1; SMN2ALOX12FGF23ALDH1A1 | |
| SCHEMBL15242410 | 0.79 | MAPT (0.39) | MAPTSMN1; SMN2CSNK1DCSNK1G2ALDH1A1 | |
| SCHEMBL12725075 | 0.79 | MAPT (0.39) | MAPTSMN1; SMN2CSNK1DCSNK1G2ALDH1A1 | |
| SCHEMBL31251637 | 0.79 | MAPT (0.62) | MAPTSMN1; SMN2ALOX12FGF23ALDH1A1 | |
| SCHEMBL11521420 | 0.76 | MAPT (1.00) | MAPTSMN1; SMN2ALOX12FGF23ALDH1A1 | |
| SCHEMBL11521418 | 0.76 | MAPT (1.00) | MAPTSMN1; SMN2ALOX12FGF23ALDH1A1 | |
| SCHEMBL16472974 | 0.76 | MAPT (1.00) | MAPTSMN1; SMN2ALOX12FGF23ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134696-A1 | Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors | FORUM PHARMACEUTICALS, INC. | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134696-A1 | Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors | CHRNA7, CHRNA5, CHRNA2 | MAPT 1008/4885SMN1; SMN2 971/4885ALOX12 1395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.