Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | FGF23 | Q9GZV9 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8943045 | 1.00 | MAPT (0.74) | MAPTSMN1; SMN2ALDH1A1HPGDALOX15 | |
| SCHEMBL11521420 | 0.85 | MAPT (1.00) | MAPTSMN1; SMN2ALDH1A1HPGDALOX15 | |
| SCHEMBL11521418 | 0.85 | MAPT (1.00) | MAPTSMN1; SMN2ALDH1A1HPGDALOX15 | |
| SCHEMBL16472974 | 0.85 | MAPT (1.00) | MAPTSMN1; SMN2ALDH1A1HPGDALOX15 | |
| SCHEMBL12724869 | 0.80 | MAPT (0.62) | MAPTSMN1; SMN2ALDH1A1HPGDALOX15 | |
| SCHEMBL31251637 | 0.80 | MAPT (0.62) | MAPTSMN1; SMN2ALDH1A1HPGDALOX15 | |
| SCHEMBL20148142 | 0.80 | MAPT (0.62) | MAPTSMN1; SMN2ALDH1A1HPGDALOX15 | |
| SCHEMBL9782953 | 0.79 | ALDH1A1 (0.59) | MAPTSMN1; SMN2ALDH1A1HPGDALOX15 | |
| SCHEMBL15828703 | 0.78 | MAPT (0.69) | MAPTSMN1; SMN2ALDH1A1HPGDALOX15 | |
| SCHEMBL1527058 | 0.77 | ALDH1A1 (0.57) | MAPTSMN1; SMN2ALDH1A1HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0584988-B1 | Process for the preparation of salicylaldoxine derivatives | ZENECA LTD (GB) | 1996-10-23 | — | — | EP | disclosed |
| US-5502254-A | Method for the preparation of 2-hydroxyarylaldoximes | ZENECA LIMITED (GB) | 1996-03-26 | — | — | US | disclosed |
| US-5399761-A | Method for the preparation of 2-hydroxyarylaldoximes | ZENECA LIMITED (GB) | 1995-03-21 | — | — | US | disclosed |
| EP-0584988-A1 | Process for the preparation of salicylaldoxine derivatives | ZENECA LIMITED (GB) | 1994-03-02 | — | — | EP | disclosed |