Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.63 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | EED | O75530 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24213969 | 0.90 | HRH3 (0.52) | HRH3KDM4EMAP4K4SMO | |
| SCHEMBL2221259 | 0.82 | HRH3 (0.47) | HRH3KDM4ESMO | |
| SCHEMBL30754057 | 0.80 | HRH3 (0.64) | HRH3 | |
| SCHEMBL30588353 | 0.79 | HRH3 (0.52) | HRH3SIRT6EEDKDM4E | |
| SCHEMBL27253445 | 0.79 | HRH3 (0.52) | HRH3SIRT6EEDKDM4ESMO | |
| SCHEMBL5041190 | 0.79 | HRH3 (0.50) | HRH3SIRT6EEDKDM4E | |
| SCHEMBL2219386 | 0.78 | SMO (0.48) | HRH3KDM4ESMO | |
| SCHEMBL20148206 | 0.78 | MAP4K4 (0.43) | HRH3KDM4EMAP4K4 | |
| SCHEMBL14843944 | 0.78 | HRH3 (1.00) | HRH3 | |
| SCHEMBL31752465 | 0.78 | HRH3 (0.54) | HRH3SIRT6EEDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134688-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134688-A1 | NOVEL COMPOUNDS | RIPK2, RIPK1, RIPK4 | HRH3 3405/4885SIRT6 2014/4885EED 3645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.