Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23328067 | 0.87 | MMP8 (0.30) | MMP8 | |
| SCHEMBL19412407 | 0.82 | MMP8 (0.32) | MMP8 | |
| SCHEMBL12039840 | 0.79 | HSD17B10 (0.31) | — | |
| SCHEMBL8840611 | 0.79 | MAPK1 (0.42) | — | |
| SCHEMBL4982402 | 0.78 | MMP8 (0.35) | MMP8LMNA | |
| SCHEMBL12039754 | 0.78 | MAPK1 (0.35) | — | |
| SCHEMBL12324459 | 0.77 | ALDH1A1 (0.31) | — | |
| SCHEMBL20998625 | 0.76 | — | — | |
| SCHEMBL1114762 | 0.76 | MMP8 (0.34) | MMP8 | |
| SCHEMBL11381525 | 0.74 | MMP8 (0.32) | MMP8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180133200-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180133200-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | MMP8 4494/4885LMNA 2631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.