Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 8/20 | 0.58 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20149087 | 0.78 | RORC (0.75) | RORC | |
| SCHEMBL349184 | 0.77 | SMN1; SMN2 (0.53) | KDM1ANPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL10683024 | 0.74 | SMN1; SMN2 (0.57) | KDM1ANPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL10683021 | 0.74 | SMN1; SMN2 (0.57) | KDM1ANPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL10683015 | 0.74 | SMN1; SMN2 (0.57) | KDM1ANPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL16472054 | 0.74 | SMN1; SMN2 (0.57) | RORCPDK1PDK2PDK3PDK4 | |
| SCHEMBL16158890 | 0.74 | SMN1; SMN2 (0.58) | KDM1ANPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL31412573 | 0.74 | SMN1; SMN2 (0.47) | KDM1ANPC1RAB9ASMN1; SMN2PDE4B | |
| SCHEMBL20149112 | 0.74 | RORC (1.00) | RORCTACR1 | |
| SCHEMBL20149129 | 0.72 | RORC (0.80) | RORCTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089406-A1 | ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |