Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FURIN | P09958 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27291528 | 0.91 | FURIN (0.49) | FURINHTTSMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL24393476 | 0.90 | FURIN (0.40) | FURINHTTSMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL22064590 | 0.90 | FURIN (0.51) | FURINHTTSMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL25124339 | 0.89 | FURIN (0.43) | FURINHTTSMN1; SMN2L3MBTL1SIRT1 | |
| SCHEMBL23387007 | 0.89 | KIF11 (0.41) | FURINHTTSMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL16769624 | 0.88 | FURIN (0.41) | FURINHTTSMN1; SMN2SIRT1SIRT2 | |
| SCHEMBL25655950 | 0.88 | FURIN (0.41) | FURINHTTSMN1; SMN2SIRT1SIRT2 | |
| SCHEMBL24220965 | 0.88 | SIRT2 (0.44) | FURINHTTSIRT1SIRT2SIRT3 | |
| SCHEMBL22268356 | 0.88 | SIRT2 (0.44) | FURINHTTSIRT1SIRT2SIRT3 | |
| SCHEMBL24220963 | 0.88 | SIRT2 (0.41) | FURINHTTSMN1; SMN2SIRT1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134717-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | SPIROGEN LIMITED (GB) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134717-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | HDAC10, PBDC1, PDCD10 | FURIN 2528/4885HTT 1453/4885SMN1; SMN2 2060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.