Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FURIN | P09958 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.38 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23344152 | 0.97 | FURIN (0.50) | FURINHTTSMN1; SMN2TP53PTPN2 | |
| SCHEMBL16847753 | 0.92 | FURIN (0.43) | FURINHTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL19466303 | 0.91 | FURIN (0.42) | FURINHTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL19466325 | 0.91 | FURIN (0.42) | FURINHTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27291528 | 0.91 | FURIN (0.49) | FURINHTTSMN1; SMN2TP53KMT2A | |
| SCHEMBL20149172 | 0.90 | FURIN (0.49) | FURINHTTSMN1; SMN2TP53KMT2A | |
| SCHEMBL26431147 | 0.90 | HTT (0.46) | FURINHTTSMN1; SMN2L3MBTL1POLB | |
| SCHEMBL19591557 | 0.89 | FURIN (0.49) | FURINHTTSIRT2SIRT1 | |
| SCHEMBL22266602 | 0.89 | ALB (0.43) | FURINHTTSMN1; SMN2POLBSIRT5 | |
| SCHEMBL22541305 | 0.88 | SIRT2 (0.44) | FURINHTTSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230233703-A1 | AMANITIN CONJUGATES | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2023-07-27 | — | — | US | disclosed |
| US-11702451-B2 | Method for synthesizing amanitins | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2023-07-18 | — | — | US | disclosed |
| US-11583569-B2 | PSMA-targeting amanitin conjugates | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2023-02-21 | — | — | US | disclosed |
| US-11236059-B2 | Targeted cytotoxic ratjadone derivatives and conjugates thereof | HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH (DE) | 2022-02-01 | — | — | US | disclosed |
| US-20210138081-A1 | Amanitin Conjugates | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2021-05-13 | — | — | US | disclosed |
| US-20210130412-A1 | METHOD FOR SYNTHESIZING AMANITINS | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2021-05-06 | — | — | US | disclosed |
| US-10961277-B2 | Method for synthesizing amanitins | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2021-03-30 | — | — | US | disclosed |
| US-20200345807-A1 | PSMA-TARGETING AMANITIN CONJUGATES | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2020-11-05 | — | — | US | disclosed |
| US-20200239426-A1 | TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF | HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH (DE) | 2020-07-30 | — | — | US | disclosed |
| US-20200181200-A1 | NOVEL METHOD FOR SYNTHESIZING AMANITINS | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2020-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230233703-A1 | AMANITIN CONJUGATES | CD47, MTX1, SIGLEC7 | FURIN 1247/4885HTT 852/4885SMN1; SMN2 2480/4885 |
| US-20200181200-A1 | NOVEL METHOD FOR SYNTHESIZING AMANITINS | CIAPIN1, ANXA5, AANAT | FURIN 1388/4885HTT 90/4885SMN1; SMN2 4801/4885 |
| US-20200345807-A1 | PSMA-TARGETING AMANITIN CONJUGATES | FOLH1, ANPEP, PSMA6 | FURIN 257/4885HTT 1961/4885SMN1; SMN2 3323/4885 |
| US-20210138081-A1 | Amanitin Conjugates | CD47, MTX1, SIGLEC7 | FURIN 1247/4885HTT 852/4885SMN1; SMN2 2480/4885 |
| US-10961277-B2 | Method for synthesizing amanitins | CIAPIN1, AANAT, ANXA5 | FURIN 1537/4885HTT 44/4885SMN1; SMN2 4795/4885 |
| US-11236059-B2 | Targeted cytotoxic ratjadone derivatives and conjugates thereof | PICALM, CD47, RABGGTB | FURIN 1454/4885HTT 1921/4885SMN1; SMN2 3847/4885 |
| US-20200239426-A1 | TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF | PICALM, CD47, RABGGTB | FURIN 1454/4885HTT 1921/4885SMN1; SMN2 3847/4885 |
| US-11583569-B2 | PSMA-targeting amanitin conjugates | FOLH1, ANPEP, PSMA6 | FURIN 257/4885HTT 1961/4885SMN1; SMN2 3323/4885 |
| US-11702451-B2 | Method for synthesizing amanitins | CIAPIN1, AANAT, ANXA5 | FURIN 1537/4885HTT 44/4885SMN1; SMN2 4795/4885 |
| US-20210130412-A1 | METHOD FOR SYNTHESIZING AMANITINS | CIAPIN1, AANAT, ANXA5 | FURIN 1537/4885HTT 44/4885SMN1; SMN2 4795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.