Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5359897 | 0.80 | KMT2A (0.36) | KMT2AMCL1GAASMN1; SMN2KDM4E | |
| SCHEMBL18249667 | 0.76 | ALDH1A1 (0.51) | KMT2AMCL1GAASMN1; SMN2KDM4E | |
| SCHEMBL22207679 | 0.74 | KMT2A (0.50) | KMT2AMCL1GAASMN1; SMN2KDM4E | |
| SCHEMBL14022267 | 0.73 | PRKCI (0.48) | KMT2AGAAKDM4EMEN1HPGD | |
| SCHEMBL28206077 | 0.72 | ALDH1A1 (0.51) | KMT2AMCL1GAASMN1; SMN2KDM4E | |
| SCHEMBL18257911 | 0.70 | KMT2A (0.78) | KMT2AGAASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL14592154 | 0.68 | ALDH1A1 (0.47) | KMT2AMCL1GAASMN1; SMN2KDM4E | |
| SCHEMBL13343501 | 0.67 | KMT2A (0.50) | KMT2AGAASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1231561 | 0.67 | HDAC1 (0.51) | KMT2AGAASMN1; SMN2KDM4E | |
| SCHEMBL19483583 | 0.67 | KMT2A (0.51) | KMT2AGAASMN1; SMN2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10273246-B2 | Methods and compositions of substituted 5H-[1,2,5] oxadiazolo [3′,4′:5,6] pyrazino[2,3-B] indole analogs as inhibitors of β-catenin/T-cell factor protein-protein interactions | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2019-04-30 | — | — | US | disclosed |
| US-20180134729-A1 | METHODS AND COMPOSITIONS OF SUBSTITUTED 5H-[1,2,5] OXADIAZOLO [3',4':5,6] PYRAZINO[2,3-B] INDOLE ANALOGS AS INHIBITORS OF BETA-CATENIN/T-CELL FACTOR PROTEIN-PROTEIN INTERACTIONS | UNIVERSITY OF UTAH | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134729-A1 | METHODS AND COMPOSITIONS OF SUBSTITUTED 5H-[1,2,5] OXADIAZOLO [3',4':5,6] PYRAZINO[2,3-B] INDOLE ANALOGS AS INHIBITORS OF BETA-CATENIN/T-CELL FACTOR PROTEIN-PROTEIN INTERACTIONS | CTNNB1, CTNNBL1, WNT3A | KMT2A 4263/4885MCL1 119/4885GAA 4808/4885 |
| US-10273246-B2 | Methods and compositions of substituted 5H-[1,2,5] oxadiazolo [3′,4′:5,6] pyrazino[2,3-B] indole analogs as inhibitors of β-catenin/T-cell factor protein-protein interactions | CTNNB1, CTNNBL1, WNT3A | KMT2A 4190/4885MCL1 122/4885GAA 4811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.