Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 8/20 | 0.56 |
| ▸ | RPTOR | Q8N122 | 8/20 | 0.56 |
| ▸ | MLST8 | Q9BVC4 | 8/20 | 0.56 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133722 | 0.87 | MTOR (0.68) | MTORRPTORMLST8SYKNPSR1 | |
| SCHEMBL22693186 | 0.82 | MTOR (0.60) | MTORRPTORMLST8SYKNPSR1 | |
| SCHEMBL20150210 | 0.82 | MTOR (0.64) | MTORRPTORMLST8MLNRKDM4E | |
| SCHEMBL20133708 | 0.82 | MTOR (0.58) | MTORRPTORMLST8SYKSMO | |
| SCHEMBL20133721 | 0.80 | MTOR (0.56) | MTORRPTORMLST8SMOCYP2D6 | |
| SCHEMBL20133723 | 0.79 | MTOR (0.55) | MTORRPTORMLST8ARPRKCQ | |
| SCHEMBL20133739 | 0.79 | MTOR (0.78) | MTORRPTORMLST8CYP2D6KDM4E | |
| SCHEMBL20149685 | 0.78 | MTOR (0.79) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20149839 | 0.78 | MTOR (0.65) | MTORRPTORMLST8MLNRKDM4E | |
| SCHEMBL20149789 | 0.78 | MTOR (0.65) | MTORRPTORMLST8MLNRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |