Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15507848 | 0.79 | ALDH1A1 (0.49) | SIRT6ALDH1A1LMNACHEK1TDP1 | |
| SCHEMBL11224598 | 0.78 | CHEK1 (0.61) | SIRT6ALDH1A1LMNACHEK1PDGFRB | |
| SCHEMBL22418960 | 0.76 | ALDH1A1 (0.49) | SIRT6ALDH1A1LMNACHEK1TDP1 | |
| SCHEMBL29212300 | 0.76 | CHEK1 (0.46) | SIRT6ALDH1A1LMNACHEK1PDGFRB | |
| SCHEMBL30184489 | 0.76 | CHEK1 (0.46) | SIRT6ALDH1A1LMNACHEK1PDGFRB | |
| SCHEMBL20091865 | 0.76 | ALDH1A1 (0.56) | ALDH1A1CHEK1TYK2TDP1TDP2 | |
| SCHEMBL26120526 | 0.76 | SIRT6 (0.48) | SIRT6ALDH1A1LMNACHEK1TDP1 | |
| SCHEMBL29740042 | 0.76 | SIRT6 (0.48) | SIRT6ALDH1A1LMNACHEK1TDP1 | |
| SCHEMBL20150168 | 0.74 | TYK2 (0.41) | ALDH1A1TYK2SMN1; SMN2MAPTHTT | |
| SCHEMBL19031189 | 0.74 | SIRT6 (0.46) | SIRT6ALDH1A1LMNACHEK1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134700-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134700-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | SIRT6 1431/4885ALDH1A1 4827/4885LMNA 2078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.