Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.45 |
| ▸ | THRB | P10828 | 4/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2650245 | 0.76 | ERN1 (0.52) | ERN1VCAM1MEN1KMT2APOLB | |
| SCHEMBL27989353 | 0.73 | ERN1 (0.52) | ERN1MEN1KMT2APOLBMAPT | |
| SCHEMBL19475595 | 0.72 | PDGFRB (0.52) | ERN1MAPTTDP1HTTLMNA | |
| SCHEMBL15703077 | 0.72 | TSHR (0.60) | THRBVCAM1MEN1KMT2ACYP3A4 | |
| SCHEMBL30908542 | 0.72 | TSHR (0.60) | THRBVCAM1MEN1KMT2ACYP3A4 | |
| SCHEMBL13593045 | 0.71 | SCD (0.57) | SCDFLT3MAP4K4TGFBR1 | |
| SCHEMBL17785771 | 0.70 | VCAM1 (0.44) | THRBVCAM1MEN1KMT2APOLB | |
| SCHEMBL11878819 | 0.70 | TSHR (0.56) | THRBVCAM1MEN1KMT2APOLB | |
| SCHEMBL20150270 | 0.70 | ATM (0.61) | THRBVCAM1MEN1KMT2ATDP1 | |
| SCHEMBL11879430 | 0.70 | VCAM1 (0.48) | ERN1THRBVCAM1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134700-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134700-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | ERN1 845/4885THRB 758/4885SCD 2833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.