SCHEMBL20150356

SCHEMBL20150356

Cc1cc(-c2ccc3c4ccc(-c5cc(C)cc(C(F)(F)F)c5)cc4n(-c4cc(C#N)ccc4-c4nc(C)nc(C)n4)c3c2)cc(C(F)(F)F)c1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SYK P43405 2/20 0.33
RXRA P19793 1/20 0.32
RXRG P48443 1/20 0.32
KIF11 P52732 1/20 0.32
GRM5 P41594 1/20 0.31
HCRTR1 O43613 1/20 0.31
HCRTR2 O43614 1/20 0.31
MAT2A P31153 1/20 0.30
GRIN1 Q05586 1/20 0.30
GRIN2B Q13224 1/20 0.30
CYP11B2 P19099 1/20 0.30
CHEK1 O14757 1/20 0.30
PSEN1 P49768 1/20 0.30
PSEN2 P49810 1/20 0.30
APH1B Q8WW43 1/20 0.30
NCSTN Q92542 1/20 0.30
APH1A Q96BI3 1/20 0.30
PSENEN Q9NZ42 1/20 0.30
DGAT1 O75907 1/20 0.30
SOAT1 P35610 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20150357 0.96 PTGER4 (0.33) SYKRXRARXRGKIF11GRM5
SCHEMBL20156274 0.95 RXRA (0.34) RXRARXRGKIF11GRM5HCRTR1
SCHEMBL20150358 0.92 HCRTR1 (0.30) HCRTR1HCRTR2
SCHEMBL20150360 0.92 SYK (0.33) SYKRXRARXRGKIF11GRM5
SCHEMBL20156275 0.91 PTGER4 (0.34) RXRARXRGKIF11GRM5GRIN1
SCHEMBL20155938 0.90
SCHEMBL20150354 0.90 CHEK1 (0.34) GRM5CYP11B2CHEK1KCNH2
SCHEMBL20150399 0.87 RXRA (0.34) RXRARXRGKIF11GRM5GRIN1
SCHEMBL20155940 0.87 RXRA (0.34) RXRARXRGKIF11GRM5MAT2A
SCHEMBL20156271 0.86 GRM5 (0.37) KIF11GRM5MAT2APSEN1PSEN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES OR10J3, EPCAM, F12 SYK 338/4885RXRA 2913/4885RXRG 2999/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.