SCHEMBL20150357

SCHEMBL20150357

Cc1cc(-c2ccc3c4ccccc4n(-c4cc(C#N)ccc4-c4nc(C)nc(C)n4)c3c2)cc(C(F)(F)F)c1

nearest known ligand 0.33

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 1/20 0.33
SYK P43405 1/20 0.33
PDPK1 O15530 1/20 0.32
GRM5 P41594 1/20 0.31
GPBAR1 Q8TDU6 1/20 0.31
KIF11 P52732 1/20 0.30
RXRA P19793 1/20 0.30
RXRG P48443 1/20 0.30
MAT2A P31153 1/20 0.30
GRIN1 Q05586 1/20 0.30
GRIN2B Q13224 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20156275 0.96 PTGER4 (0.34) PTGER4PDPK1GRM5GPBAR1KIF11
SCHEMBL20150356 0.96 SYK (0.33) SYKGRM5KIF11RXRARXRG
SCHEMBL20114553 0.91 PTGER4 (0.36) PTGER4GRM5
SCHEMBL20156274 0.91 RXRA (0.34) PDPK1GRM5GPBAR1KIF11RXRA
SCHEMBL20150360 0.89 SYK (0.33) PTGER4SYKGRM5KIF11RXRA
SCHEMBL20150358 0.89 HCRTR1 (0.30)
SCHEMBL20155963 0.89 PTGER4 (0.34) PTGER4PDPK1GRM5GPBAR1KIF11
SCHEMBL20155938 0.88
SCHEMBL20114533 0.87 KIF11 (0.42) PTGER4PDPK1GRM5GPBAR1KIF11
SCHEMBL20150364 0.87 PTGER4 (0.35) PTGER4SYKGRM5RXRARXRG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES OR10J3, EPCAM, F12 PTGER4 1809/4885SYK 338/4885PDPK1 4159/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.