SCHEMBL2015046

SCHEMBL2015046

COc1cc(C(=O)N(C)C(CCNC(=O)c2cccn2C)Cc2ccccc2)c2ncccc2c1OC

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 2/20 0.57
HCRTR2 O43614 2/20 0.57
PABPC1 P11940 1/20 0.41
CASP7 P55210 1/20 0.41
CASP6 P55212 1/20 0.41
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
KDM4E B2RXH2 1/20 0.37
NSD2 O96028 1/20 0.37
MAPT P10636 1/20 0.37
HSP90AA1 P07900 1/20 0.37
HSP90AB1 P08238 1/20 0.37
HRH3 Q9Y5N1 2/20 0.37
ADRA1D P25100 1/20 0.37
ADRA1A P35348 1/20 0.37
ADRA1B P35368 1/20 0.37
ITGA4 P13612 1/20 0.36
ITGB7 P26010 1/20 0.36
POLB P06746 1/20 0.36
PADI4 Q9UM07 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2054405 1.00 HCRTR1 (0.57) HCRTR1HCRTR2PABPC1CASP7CASP6
SCHEMBL2015171 0.85 HCRTR1 (0.60) HCRTR1HCRTR2CASP7CASP6NPC1
SCHEMBL2010795 0.84 HCRTR1 (0.62) HCRTR1HCRTR2NPC1RAB9AMAPT
SCHEMBL2054013 0.84 HCRTR1 (0.62) HCRTR1HCRTR2NPC1RAB9AMAPT
SCHEMBL2010789 0.82 HCRTR1 (0.58) HCRTR1HCRTR2NPC1RAB9AHRH3
SCHEMBL2015844 0.82 HCRTR1 (0.62) HCRTR1HCRTR2NPC1RAB9AHRH3
SCHEMBL2012888 0.82 HCRTR1 (0.62) HCRTR1HCRTR2NPC1RAB9AHRH3
SCHEMBL2012875 0.82 HCRTR1 (0.58) HCRTR1HCRTR2NPC1RAB9AHRH3
SCHEMBL2012874 0.82 HCRTR1 (0.58) HCRTR1HCRTR2NPC1RAB9AHRH3
SCHEMBL2013911 0.81 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO claimed
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO disclosed