Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.60 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2010789 | 0.90 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9AEGLN1 | |
| SCHEMBL2013457 | 0.89 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9AALDH1A1 | |
| SCHEMBL2054419 | 0.89 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9AALDH1A1 | |
| SCHEMBL2012875 | 0.89 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9AEGLN1 | |
| SCHEMBL2012874 | 0.89 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9AEGLN1 | |
| SCHEMBL2015844 | 0.88 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9AKMT2A | |
| SCHEMBL2012888 | 0.88 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9AKMT2A | |
| SCHEMBL2015046 | 0.85 | HCRTR1 (0.57) | HCRTR1HCRTR2NPC1RAB9AKDM4E | |
| SCHEMBL2054405 | 0.85 | HCRTR1 (0.57) | HCRTR1HCRTR2NPC1RAB9AKDM4E | |
| SCHEMBL2054013 | 0.85 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |