Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.72 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.72 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013804 | 0.94 | HCRTR1 (0.73) | HCRTR1HCRTR2NPC1RAB9ACTSL | |
| SCHEMBL2010953 | 0.88 | HCRTR1 (0.69) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL13139060 | 0.87 | HCRTR1 (0.77) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL13139093 | 0.86 | HCRTR1 (0.77) | HCRTR1HCRTR2NPC1RAB9ACTSL | |
| SCHEMBL2010792 | 0.86 | HCRTR1 (0.67) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2017387 | 0.85 | HCRTR1 (0.71) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL6920111 | 0.85 | HCRTR1 (0.68) | HCRTR1HCRTR2NPC1RAB9ACTSL | |
| SCHEMBL2015121 | 0.85 | HCRTR1 (0.65) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL6919915 | 0.85 | HCRTR1 (0.65) | HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL2012115 | 0.85 | HCRTR1 (0.65) | HCRTR1HCRTR2NPC1RAB9APADI4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |