Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.68 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.38 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2010792 | 0.89 | HCRTR1 (0.67) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL6919915 | 0.86 | HCRTR1 (0.65) | HCRTR1HCRTR2NPC1RAB9AKIFC1 | |
| SCHEMBL2013804 | 0.86 | HCRTR1 (0.73) | HCRTR1HCRTR2NPC1RAB9ACTSV | |
| SCHEMBL2015048 | 0.85 | HCRTR1 (0.72) | HCRTR1HCRTR2NPC1RAB9ACTSL | |
| SCHEMBL13139093 | 0.84 | HCRTR1 (0.77) | HCRTR1HCRTR2NPC1RAB9ACTSL | |
| SCHEMBL13139060 | 0.83 | HCRTR1 (0.77) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2012115 | 0.83 | HCRTR1 (0.65) | HCRTR1HCRTR2NPC1RAB9AALDH1A1 | |
| SCHEMBL2015121 | 0.83 | HCRTR1 (0.65) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2010953 | 0.83 | HCRTR1 (0.69) | HCRTR1HCRTR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13139074 | 0.82 | HCRTR1 (0.84) | HCRTR1HCRTR2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |