Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | RAD52 | P43351 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983102 | 0.88 | KDM4E (0.46) | POLBRAD52KDM4EHTTUSP2 | |
| SCHEMBL3972718 | 0.83 | KDM4E (0.50) | POLBRAD52KDM4EHTTUSP2 | |
| Ammonia Solution, Strong SCHEMBL28150012 | 0.81 | TLR8 (0.49) | KDM4EUSP2ALDH1A1GLAGAA | |
| SCHEMBL17471655 | 0.78 | KDM4E (0.46) | POLBRAD52KDM4EHTTUSP2 | |
| SCHEMBL6983097 | 0.78 | KDM4E (0.46) | POLBKDM4EHTTUSP2KMT2A | |
| SCHEMBL27529063 | 0.77 | KDM4E (0.50) | POLBKDM4EHTTUSP2KMT2A | |
| SCHEMBL11343689 | 0.77 | KMT2A (0.53) | POLBKDM4EHTTUSP2KMT2A | |
| SCHEMBL30517871 | 0.77 | KMT2A (0.53) | POLBKDM4EHTTUSP2KMT2A | |
| Hydrochloric Acid SCHEMBL6629225 | 0.75 | KMT2A (0.52) | POLBRAD52KDM4EHTTUSP2 | |
| SCHEMBL12020235 | 0.74 | TLR7 (0.42) | KDM4EHTTUSP2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134727-A1 | Inhibitors of RAD52 Recombination Protein and Methods Using Same | DREXEL UNIVERSITY (US) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134727-A1 | Inhibitors of RAD52 Recombination Protein and Methods Using Same | RAD52, RAD50, MRE11 | POLB 146/4885RAD52 1/4885KDM4E 1934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.