Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972714 | 0.85 | KDM4E (0.49) | KDM4EHTTUSP2MAOAMAOB | |
| SCHEMBL6983102 | 0.82 | KDM4E (0.46) | KDM4EHTTUSP2MAOAMAOB | |
| SCHEMBL5910669 | 0.81 | KDM4E (0.53) | KDM4EHTTUSP2MAOAMAOB | |
| SCHEMBL27529063 | 0.81 | KDM4E (0.50) | KDM4EHTTUSP2KMT2AMAPT | |
| SCHEMBL30517871 | 0.81 | KMT2A (0.53) | KDM4EHTTUSP2MAOAMAOB | |
| SCHEMBL11343689 | 0.81 | KMT2A (0.53) | KDM4EHTTUSP2MAOAMAOB | |
| SCHEMBL3972718 | 0.79 | KDM4E (0.50) | KDM4EHTTUSP2MAOAMAOB | |
| Hydrochloric Acid SCHEMBL6629225 | 0.79 | KMT2A (0.52) | KDM4EHTTUSP2MAOAMAOB | |
| SCHEMBL7262454 | 0.79 | KDM4E (0.40) | KDM4EKMT2AHPGDALDH1A1GAA | |
| SCHEMBL6964689 | 0.79 | CYP1A2 (0.56) | KDM4EHTTKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299379-A2 | LACTAM METALLOPROTEASE INHIBITORS | Bristol-Myers Squibb Pharma Company (US) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002004416-A2 | LACTAM METALLOPROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2002-01-17 | — | — | WO | disclosed |