Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | RAD52 | P43351 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20150846 | 0.88 | POLB (0.44) | KDM4EHTTUSP2MAOAMAOB | |
| SCHEMBL3972718 | 0.87 | KDM4E (0.50) | KDM4EHTTUSP2MAOAMAOB | |
| SCHEMBL17471655 | 0.82 | KDM4E (0.46) | KDM4EHTTUSP2MAOAMAOB | |
| SCHEMBL6983097 | 0.82 | KDM4E (0.46) | KDM4EHTTUSP2MAOAMAOB | |
| SCHEMBL27529063 | 0.81 | KDM4E (0.50) | KDM4EHTTUSP2ALDH1A1GAA | |
| SCHEMBL11343689 | 0.81 | KMT2A (0.53) | KDM4EHTTUSP2MAOAMAOB | |
| SCHEMBL30517871 | 0.81 | KMT2A (0.53) | KDM4EHTTUSP2MAOAMAOB | |
| SCHEMBL7262455 | 0.80 | KDM4E (0.43) | KDM4EMAOAALDH1A1GAAPOLB | |
| SCHEMBL4264705 | 0.80 | KDM4E (0.47) | KDM4EALDH1A1GAAPOLBRAD52 | |
| Hydrochloric Acid SCHEMBL6629225 | 0.79 | KMT2A (0.52) | KDM4EHTTUSP2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299379-A2 | LACTAM METALLOPROTEASE INHIBITORS | Bristol-Myers Squibb Pharma Company (US) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002004416-A2 | LACTAM METALLOPROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2002-01-17 | — | — | WO | disclosed |