SCHEMBL4434201

SCHEMBL4434201

NCCc1cc2c(Cl)cccc2nc1-c1cccc(F)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 3/20 0.47
NT5E P21589 1/20 0.44
TAAR1 Q96RJ0 6/20 0.43
DPP4 P27487 2/20 0.41
MAPK1 P28482 3/20 0.40
USP2 O75604 2/20 0.40
CYP1A2 P05177 2/20 0.40
CYP3A4 P08684 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
ALDH1A1 P00352 2/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
HSD17B10 Q99714 1/20 0.38
TACR3 P29371 2/20 0.38
ADORA1 P30542 2/20 0.37
ADORA2B P29275 1/20 0.37
PTGDR2 Q9Y5Y4 1/20 0.36
KDM4E B2RXH2 1/20 0.36
XBP1 P17861 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4435275 0.88 NT5E (0.44) ADORA2ANT5EDPP4MAPK1USP2
SCHEMBL4441914 0.79 SMN1; SMN2 (0.51) ADORA2ANT5EMAPK1USP2CYP1A2
SCHEMBL19331478 0.79 TAAR1 (0.47) ADORA2ATAAR1DPP4MAPK1USP2
SCHEMBL2015151 0.79 SYK (0.45) ADORA2ATAAR1DPP4USP2CYP1A2
SCHEMBL4437114 0.75 MAP4K4 (0.41) ADORA2ATAAR1MAPK1USP2CYP1A2
SCHEMBL4174797 0.75 NT5E (0.50) ADORA2ANT5EMAPK1USP2CYP1A2
SCHEMBL4178011 0.75 ADORA2A (0.47) ADORA2ANT5EDPP4CYP1A2CYP3A4
SCHEMBL4434943 0.75 NPC1 (0.41) ADORA2ATAAR1DPP4KMT2AADORA1
SCHEMBL4437511 0.75 TAAR1 (0.43) ADORA2ANT5ETAAR1DPP4MAPK1
SCHEMBL2717755 0.74 NT5E (0.46) ADORA2ANT5ETAAR1DPP4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2137186-A1 HETEROCYCLIC COMPOUNDS AND THEIR USES Amgen Inc. (US) 2009-12-30 EP disclosed
WO-2008118468-A1 HETEROCYCLIC COMPOUNDS AND THEIR USES AMGEN INC. (US) 2008-10-02 WO disclosed