Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015196 | 0.72 | AR (0.33) | KDM4ESMN1; SMN2HSD17B10FABP3FABP4 | |
| SCHEMBL18817131 | 0.71 | KDM4E (0.41) | KDM4EKMT2ASMN1; SMN2HSD17B10FABP3 | |
| SCHEMBL21486187 | 0.70 | TRPM8 (0.37) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL25615395 | 0.67 | PDE4A (0.38) | KDM4EKMT2ASMN1; SMN2HSD17B10CDK8 | |
| SCHEMBL25614912 | 0.67 | L3MBTL1 (0.39) | KDM4EKMT2ASMN1; SMN2HSD17B10CDK8 | |
| SCHEMBL28115563 | 0.67 | KMT2A (0.37) | KDM4EKMT2ASMN1; SMN2HSD17B10TP53 | |
| SCHEMBL1666394 | 0.66 | SMN1; SMN2 (0.52) | KDM4EKMT2ASMN1; SMN2HSD17B10MAPT | |
| SCHEMBL1666977 | 0.66 | SMN1; SMN2 (0.50) | KDM4EKMT2ASMN1; SMN2HSD17B10MAPT | |
| SCHEMBL25428412 | 0.64 | AKT2 (0.50) | KDM4EKMT2ASMN1; SMN2HSD17B10TP53 | |
| SCHEMBL28211222 | 0.64 | BRD4 (0.45) | KDM4EKMT2ASMN1; SMN2HSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |