Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | PARP1 | P09874 | 3/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20036994 | 0.87 | KDM4E (0.43) | ALDH1A1USP2MAPK1MCHR1KDM4E | |
| SCHEMBL20152906 | 0.72 | PARP1 (0.45) | POLBMAPK1PARP1 | |
| SCHEMBL20152907 | 0.69 | PARP1 (0.42) | ALDH1A1CYP1A2KMT2APARP1MEN1 | |
| SCHEMBL14550565 | 0.68 | GAA (0.45) | ALDH1A1POLBKDM4EHSD17B10CYP1A2 | |
| SCHEMBL839815 | 0.67 | HTR2A (0.50) | MCHR1KMT2AMEN1 | |
| SCHEMBL29539173 | 0.67 | HTR2A (0.50) | MCHR1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL20139551 | 0.66 | HTR2A (0.49) | MCHR1KMT2AMEN1 | |
| SCHEMBL12059557 | 0.65 | ALDH1A1 (0.40) | ALDH1A1POLBUSP2MCHR1KDM4E | |
| SCHEMBL6922315 | 0.65 | ALDH1A1 (0.38) | ALDH1A1USP2MCHR1KDM4EHSD17B10 | |
| SCHEMBL24097903 | 0.65 | PDCD1 (0.34) | ALDH1A1POLBTDP1L3MBTL1PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134722-A1 | AZA-PHENALENE-3-KETONE DERIVATIVE, PREPARATION METHOD THEREOF, AND ITS APPLICATION AS PARP INHIBITOR | SUZHOU KANGRUN PHARMACEUTICALS INC. (CN) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134722-A1 | AZA-PHENALENE-3-KETONE DERIVATIVE, PREPARATION METHOD THEREOF, AND ITS APPLICATION AS PARP INHIBITOR | PARP1, PARP11, PARP3 | ALDH1A1 812/4885POLB 586/4885USP2 3453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.