Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | POLR1A | O95602 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | DTYMK | P23919 | 2/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20036990 | 0.90 | NR1H2 (0.49) | PARP1TNKS2PARP2NR1H2POLB | |
| SCHEMBL20152907 | 0.82 | PARP1 (0.42) | PARP1TNKS2PARP2TSHRHTT | |
| SCHEMBL20139779 | 0.78 | TSHR (0.62) | NR1H2POLBTSHRHTTOPRM1 | |
| SCHEMBL31029028 | 0.76 | NR1H2 (0.44) | PARP1TNKS2PARP2NR1H2POLB | |
| SCHEMBL27432553 | 0.76 | NR1H2 (0.44) | PARP1TNKS2PARP2NR1H2POLB | |
| SCHEMBL20161153 | 0.73 | ALDH1A1 (0.43) | PARP1TNKS2PARP2TSHRHTT | |
| SCHEMBL20152908 | 0.72 | ALDH1A1 (0.35) | PARP1POLBMAPK1 | |
| SCHEMBL1231827 | 0.72 | GBA1 (0.44) | NR1H2POLBTSHRHTTMAPK1 | |
| SCHEMBL13575666 | 0.70 | CKS1B (0.48) | NR1H2TSHRMAPK1GBA1LIPG | |
| SCHEMBL27432394 | 0.70 | NR1H2 (0.45) | PARP1TNKS2PARP2NR1H2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134722-A1 | AZA-PHENALENE-3-KETONE DERIVATIVE, PREPARATION METHOD THEREOF, AND ITS APPLICATION AS PARP INHIBITOR | SUZHOU KANGRUN PHARMACEUTICALS INC. (CN) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134722-A1 | AZA-PHENALENE-3-KETONE DERIVATIVE, PREPARATION METHOD THEREOF, AND ITS APPLICATION AS PARP INHIBITOR | PARP1, PARP11, PARP3 | PARP1 1/4885TNKS2 33/4885PARP2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.