SCHEMBL20152973

SCHEMBL20152973

COc1ccc(O)c2c1CCC2c1cc(-c2ccccc2)ccc1O

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 1/20 0.42
PIN1 Q13526 1/20 0.39
CETP P11597 1/20 0.39
ACLY P53396 2/20 0.38
PPIB P23284 1/20 0.38
PPIA P62937 1/20 0.38
MGLL Q99685 1/20 0.37
WDR5 P61964 1/20 0.37
IDO1 P14902 1/20 0.37
ALOX5 P09917 1/20 0.36
FYN P06241 1/20 0.36
CHEK1 O14757 1/20 0.36
FGFR1 P11362 1/20 0.36
CDK4 P11802 1/20 0.36
CCNA2 P20248 1/20 0.36
CCND1 P24385 1/20 0.36
CDK2 P24941 1/20 0.36
CCND3 P30281 1/20 0.36
KDR P35968 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20152956 0.82 PDE4A (0.38) CETP
SCHEMBL20152922 0.81 PDE1B (0.44) CETPWDR5
SCHEMBL20153027 0.69 MEN1 (0.36)
SCHEMBL2524920 0.69 POLB (0.62) IDO1ALOX5FYNCHEK1FGFR1
SCHEMBL30957832 0.69 POLB (0.62) IDO1ALOX5FYNCHEK1FGFR1
SCHEMBL27619310 0.69 ALOX5 (0.57) ACLYIDO1ALOX5
SCHEMBL2277992 0.67 HTR2C (0.48) HTR2C
SCHEMBL9379302 0.67 FYN (0.52) ACLYWDR5IDO1ALOX5FYN
SCHEMBL8922452 0.66 CDK4 (0.51) ACLYWDR5ALOX5FYNCHEK1
SCHEMBL20152962 0.65 TP53 (0.39) HTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018086197-A1 CATALYTIC ASYMMETRIC SYNTHESIS METHOD FOR CHIRAL SPINOL DERIVATE 南方科技大学 2018-05-17 WO disclosed