Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF2 | Q12772 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 8/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3603144 | 0.83 | RAB9A (0.75) | SREBF2KDM4EKMT2AARRAB9A | |
| SCHEMBL17336836 | 0.83 | RAB9A (0.75) | SREBF2KDM4EKMT2AARRAB9A | |
| SCHEMBL14849638 | 0.83 | PTGDR2 (0.50) | KDM4EKMT2AMAPTALDH1A1POLB | |
| SCHEMBL11215130 | 0.81 | SREBF2 (0.82) | SREBF2KDM4EKMT2AARRAB9A | |
| SCHEMBL11213828 | 0.81 | SREBF2 (0.82) | SREBF2KDM4EKMT2AARRAB9A | |
| SCHEMBL11212983 | 0.81 | SREBF2 (0.82) | SREBF2KDM4EKMT2AARRAB9A | |
| SCHEMBL11464717 | 0.79 | SREBF2 (0.79) | SREBF2KDM4EKMT2AARRAB9A | |
| SCHEMBL2781370 | 0.79 | KDM4E (0.85) | SREBF2KDM4EKMT2AARRAB9A | |
| SCHEMBL66549 | 0.79 | CDC7 (0.60) | KDM4EKMT2AARRAB9ASMN1; SMN2 | |
| SCHEMBL17336676 | 0.74 | RAB9A (0.66) | SREBF2KDM4EKMT2AARRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9974795-B2 | Anticancer agent composition | CARNA BIOSCIENCES, INC. (JP) | 2018-05-22 | — | — | US | claimed |