Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.75 |
| ▸ | LMNA | P02545 | 4/20 | 0.75 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.70 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.69 |
| ▸ | AR | P10275 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 6/20 | 0.64 |
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17336836 | 1.00 | RAB9A (0.75) | RAB9AKDM4ESMN1; SMN2LMNASREBF2 | |
| SCHEMBL11213828 | 0.91 | SREBF2 (0.82) | RAB9AKDM4ESMN1; SMN2LMNASREBF2 | |
| SCHEMBL11212983 | 0.91 | SREBF2 (0.82) | RAB9AKDM4ESMN1; SMN2LMNASREBF2 | |
| SCHEMBL11215130 | 0.91 | SREBF2 (0.82) | RAB9AKDM4ESMN1; SMN2LMNASREBF2 | |
| SCHEMBL11464717 | 0.89 | SREBF2 (0.79) | RAB9AKDM4ESMN1; SMN2LMNASREBF2 | |
| SCHEMBL2781370 | 0.89 | KDM4E (0.85) | RAB9AKDM4ESMN1; SMN2LMNASREBF2 | |
| SCHEMBL7532072 | 0.84 | KDM4E (0.73) | RAB9AKDM4ESMN1; SMN2LMNASREBF2 | |
| SCHEMBL26123239 | 0.84 | KDM4E (0.73) | RAB9AKDM4ESMN1; SMN2LMNASREBF2 | |
| SCHEMBL26118261 | 0.84 | KDM4E (0.73) | RAB9AKDM4ESMN1; SMN2LMNASREBF2 | |
| SCHEMBL28493960 | 0.84 | SMN1; SMN2 (0.73) | RAB9AKDM4ESMN1; SMN2LMNASREBF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101265258-B | Organic material and application thereof in organic electroluminescence device | UNIV TSINGHUA | 2011-03-30 | — | — | CN | disclosed |
| CN-101663298-A | Thiazole derivatives as modulators of g protein-coupled receptors | IRM LLC | 2010-03-03 | — | — | CN | disclosed |
| US-20100022592-A1 | THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2010-01-28 | — | — | US | disclosed |
| US-20100022592-A1 | THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2010-01-28 | — | — | US | disclosed |
| EP-2121675-A1 | THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2009-11-25 | — | — | EP | disclosed |
| CN-101265258-A | Organic material and application thereof in organic electroluminescence device | UNIV TSINGHUA (CN) | 2008-09-17 | — | — | CN | disclosed |
| WO-2008103500-A1 | THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2008-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022592-A1 | THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS | GPR119, GPR65, GPR180 | RAB9A 2377/4885KDM4E 4170/4885SMN1; SMN2 4681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.