Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.57 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2049937 | 1.00 | HCRTR1 (0.57) | HCRTR1HCRTR2L3MBTL1NPC1RAB9A | |
| SCHEMBL2015135 | 0.91 | HCRTR1 (0.59) | HCRTR1HCRTR2L3MBTL1NPC1RAB9A | |
| SCHEMBL2010469 | 0.87 | HCRTR1 (0.57) | HCRTR1HCRTR2L3MBTL1NPC1RAB9A | |
| SCHEMBL2054315 | 0.87 | HCRTR1 (0.57) | HCRTR1HCRTR2L3MBTL1NPC1RAB9A | |
| SCHEMBL2054210 | 0.81 | HCRTR1 (0.60) | HCRTR1HCRTR2NPC1RAB9AKMT2A | |
| SCHEMBL2054212 | 0.81 | HCRTR1 (0.60) | HCRTR1HCRTR2NPC1RAB9AKMT2A | |
| SCHEMBL13139060 | 0.81 | HCRTR1 (0.77) | HCRTR1HCRTR2NPC1RAB9AKMT2A | |
| SCHEMBL2010539 | 0.80 | HCRTR1 (0.63) | HCRTR1HCRTR2NPC1RAB9AHDAC6 | |
| SCHEMBL6919915 | 0.80 | HCRTR1 (0.65) | HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL2015468 | 0.80 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |