SCHEMBL20153302

SCHEMBL20153302

Cc1cncc(-c2nccs2)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 8/20 0.54
PDPK1 O15530 1/20 0.46
SMPD3 Q9NY59 1/20 0.44
ADRB2 P07550 1/20 0.41
LOXL2 Q9Y4K0 1/20 0.41
HCRTR2 O43614 2/20 0.39
CYP3A4 P08684 2/20 0.39
HCRTR1 O43613 1/20 0.39
CHEK2 O96017 1/20 0.38
SRC P12931 1/20 0.37
ZAP70 P43403 1/20 0.37
SYK P43405 1/20 0.37
NPC1 O15118 1/20 0.36
PKM P14618 1/20 0.36
RECQL P46063 1/20 0.36
RAB9A P51151 1/20 0.36
MET P08581 1/20 0.35
CYP2E1 P05181 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10013472 0.80 SMPD3 (0.53) CYP2A6PDPK1SMPD3ADRB2LOXL2
SCHEMBL3386179 0.78 CYP2A6 (0.53) CYP2A6PDPK1SMPD3ADRB2LOXL2
SCHEMBL14908855 0.78 CYP2A6 (0.53) CYP2A6PDPK1SMPD3ADRB2LOXL2
SCHEMBL2715410 0.78 CYP2A6 (0.53) CYP2A6PDPK1SMPD3ADRB2LOXL2
SCHEMBL252833 0.78 CYP2A6 (0.53) CYP2A6PDPK1SMPD3ADRB2LOXL2
SCHEMBL31014248 0.77 SMPD3 (0.51) CYP2A6PDPK1SMPD3ADRB2CYP3A4
SCHEMBL21282891 0.77 CYP2A6 (0.49) CYP2A6PDPK1SMPD3ADRB2LOXL2
SCHEMBL7079127 0.75 PDPK1 (0.67) CYP2A6PDPK1ADRB2LOXL2CHEK2
SCHEMBL7939469 0.74 HCRTR2 (0.58) CYP2A6HCRTR2CYP3A4HCRTR1
SCHEMBL13025 0.74 PDPK1 (0.60) CYP2A6PDPK1SMPD3ADRB2LOXL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3538525-B1 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2022-06-22 EP disclosed
EP-3538519-B1 INDAZOLE DERIVATIVES AS ALPHA V INTEGRIN ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2021-07-28 EP disclosed
EP-3538528-B1 PYRROLE AMIDES AS ALPHA V INTEGRIN INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2020-12-23 EP disclosed
WO-2018089353-A1 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-05-17 WO disclosed
WO-2018089360-A1 PYRROLE AMIDES AS ALPHA V INTEGRIN INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-05-17 WO disclosed
WO-2018089355-A1 CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-05-17 WO disclosed
WO-2018089357-A1 INDAZOLE DERIVATIVES AS αV INTEGRIN ANTAGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-05-17 WO disclosed