SCHEMBL14908855

SCHEMBL14908855

Brc1cncc(-c2nccs2)c1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 5/20 0.53
PDPK1 O15530 1/20 0.46
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
LOXL2 Q9Y4K0 1/20 0.41
SMPD3 Q9NY59 1/20 0.40
ABL1 P00519 1/20 0.39
BCR P11274 1/20 0.39
PTK2 Q05397 1/20 0.39
ADRB2 P07550 1/20 0.38
CHEK2 O96017 1/20 0.38
ADORA2A P29274 1/20 0.37
HDAC6 Q9UBN7 1/20 0.36
CYP11B1 P15538 2/20 0.35
CYP11B2 P19099 2/20 0.35
LGALS1 P09382 1/20 0.34
LGALS3 P17931 1/20 0.34
KDR P35968 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL252833 0.78 CYP2A6 (0.53) CYP2A6PDPK1NPC1RAB9ALOXL2
SCHEMBL2715410 0.78 CYP2A6 (0.53) CYP2A6PDPK1LOXL2SMPD3ADRB2
SCHEMBL3386179 0.78 CYP2A6 (0.53) CYP2A6PDPK1LOXL2SMPD3ADRB2
SCHEMBL20153302 0.78 CYP2A6 (0.54) CYP2A6PDPK1NPC1RAB9ALOXL2
SCHEMBL7079127 0.75 PDPK1 (0.67) CYP2A6PDPK1RAB9ALOXL2ADRB2
SCHEMBL7609803 0.74 PDPK1 (0.60) CYP2A6PDPK1NPC1RAB9ASMN1; SMN2
SCHEMBL3327398 0.74 CYP2A6 (0.62) CYP2A6PDPK1RAB9ALOXL2SMPD3
SCHEMBL16159900 0.74 CYP2A6 (0.53) CYP2A6PDPK1RAB9ALOXL2SMPD3
SCHEMBL21282891 0.74 CYP2A6 (0.49) CYP2A6PDPK1LOXL2SMPD3ADRB2
SCHEMBL3389168 0.74 CYP2A6 (0.49) CYP2A6PDPK1LOXL2SMPD3ADRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747247-A1 NOVEL FATTY ACID AMIDE HYDROLASE MODULATORS, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF Apogee Pharmaceuticals, Inc. (CA) 2026-05-27 EP disclosed
US-12410137-B2 Fatty acid amide hydrolase modulators, compositions comprising the same and uses thereof APOGEE PHARMACEUTICALS, INC. (CA) 2025-09-09 US disclosed
US-20250129027-A1 FATTY ACID AMIDE HYDROLASE MODULATORS, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF APOGEE PHARMACEUTICALS, INC. (CA) 2025-04-24 US disclosed
WO-2025015420-A1 NOVEL FATTY ACID AMIDE HYDROLASE MODULATORS, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF APOGEE PHARMACEUTICALS, INC. (CA) 2025-01-23 WO disclosed
EP-2589592-B1 NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF FUJIFILM CORP (JP) 2018-08-22 EP disclosed
US-20160118598-A1 ELECTRON TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME JNC CORPORATION (JP) 2016-04-28 US disclosed
US-8895585-B2 Nicotinamide derivative or salt thereof FUJIFILM CORPORATION (JP) 2014-11-25 US disclosed
US-8895585-B2 Nicotinamide derivative or salt thereof FUJIFILM CORPORATION (JP) 2014-11-25 US disclosed
US-8895585-B2 Nicotinamide derivative or salt thereof FUJIFILM CORPORATION (JP) 2014-11-25 US disclosed
US-8809371-B2 2014-08-19 US disclosed
US-8809371-B2 2014-08-19 US disclosed
US-8809371-B2 2014-08-19 US disclosed
US-8772320-B2 2014-07-08 US disclosed
US-8772320-B2 2014-07-08 US disclosed
US-20130116430-A1 NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF FUJIFILM CORPORATION (JP) 2013-05-09 US disclosed
US-20130116430-A1 NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF FUJIFILM CORPORATION (JP) 2013-05-09 US disclosed
US-20130116430-A1 NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF FUJIFILM CORPORATION (JP) 2013-05-09 US disclosed
EP-2589592-A1 NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF FUJIFILM Corporation (JP) 2013-05-08 EP disclosed
EP-2589592-A1 NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF FUJIFILM Corporation (JP) 2013-05-08 EP disclosed
CN-102958918-A Novel nicotinamide derivatives or salts thereof FUJIFILM CORP 2013-03-06 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130116430-A1 NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF SYK, CD38, BTK CYP2A6 3349/4885PDPK1 2634/4885NPC1 1367/4885
US-20250129027-A1 FATTY ACID AMIDE HYDROLASE MODULATORS, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF FAAH, FAAH2, MGLL CYP2A6 232/4885PDPK1 1510/4885NPC1 1197/4885
US-12410137-B2 Fatty acid amide hydrolase modulators, compositions comprising the same and uses thereof FAAH, FAAH2, MGLL CYP2A6 232/4885PDPK1 1510/4885NPC1 1197/4885
US-20160118598-A1 ELECTRON TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME HVCN1, VDAC1, SLC26A3 CYP2A6 1206/4885PDPK1 4680/4885NPC1 1112/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.