SCHEMBL20153319

SCHEMBL20153319

Cc1cncc(-n2ccccc2=O)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
CA14 Q9ULX7 1/20 0.40
CYP1A2 P05177 2/20 0.40
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.40
HPGD P15428 1/20 0.40
BLM P54132 1/20 0.40
HSD17B10 Q99714 1/20 0.40
GABRA1 P14867 1/20 0.38
GABRA5 P31644 1/20 0.38
F10 P00742 3/20 0.37
HRH4 Q9H3N8 1/20 0.37
CYP3A4 P08684 5/20 0.36
CYP2C9 P11712 5/20 0.36
CYP2D6 P10635 1/20 0.35
CHRNB2 P17787 2/20 0.35
CHRNB4 P30926 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31456682 1.00 CA12 (0.40) CA12CA1CA2CA9CA14
SCHEMBL31456717 0.80 CHRNB2 (0.43) CA12CA1CA2CA9CA14
SCHEMBL17059032 0.80 COMT (0.49) CYP1A2KDM4EALDH1A1HPGDBLM
SCHEMBL31456616 0.79 CA12 (0.40) CA12CA1CA2CA9CA14
SCHEMBL31456691 0.79 CA12 (0.40) CA12CA1CA2CA9CA14
SCHEMBL14909303 0.79 HTT (0.40) CA12CA1CA2CA9CA14
SCHEMBL31456692 0.79 CA12 (0.40) CA12CA1CA2CA9CA14
SCHEMBL21317456 0.79 CA12 (0.38) CA12CA1CA2CA9CA14
SCHEMBL20688863 0.78 TYK2 (0.39) GABRA1GABRA5CHRNB2CHRNB4CHRNA3
SCHEMBL25614740 0.77 GABRA1 (0.37) CA12CA1CA2CA9CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3538525-B1 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2022-06-22 EP disclosed
EP-3538519-B1 INDAZOLE DERIVATIVES AS ALPHA V INTEGRIN ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2021-07-28 EP disclosed
EP-3538528-B1 PYRROLE AMIDES AS ALPHA V INTEGRIN INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2020-12-23 EP disclosed
WO-2018089357-A1 INDAZOLE DERIVATIVES AS αV INTEGRIN ANTAGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-05-17 WO disclosed
WO-2018089360-A1 PYRROLE AMIDES AS ALPHA V INTEGRIN INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-05-17 WO disclosed
WO-2018089353-A1 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-05-17 WO disclosed
WO-2018089355-A1 CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-05-17 WO disclosed