Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.65 |
| ▸ | ITGB3 | P05106 | 19/20 | 0.65 |
| ▸ | ITGB6 | P18564 | 8/20 | 0.57 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.57 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.57 |
| ▸ | ITGB8 | P26012 | 5/20 | 0.57 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.57 |
| ▸ | ITGB5 | P18084 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20153363 | 0.98 | ITGAV (0.64) | ITGAVITGB3ITGB6ITGB1ITGA5 | |
| SCHEMBL24521912 | 0.86 | ITGB3 (0.59) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL24521990 | 0.81 | ITGAV (0.64) | ITGAVITGB3ITGB6ITGB1ITGA5 | |
| SCHEMBL21294604 | 0.80 | ITGAV (0.72) | ITGAVITGB3ITGB6ITGB1ITGA5 | |
| SCHEMBL6421095 | 0.79 | ITGAV (1.00) | ITGAVITGB3ITGB6ITGB1ITGA5 | |
| SCHEMBL6358670 | 0.79 | ITGAV (1.00) | ITGAVITGB3ITGB6ITGB1ITGA5 | |
| SCHEMBL6421090 | 0.79 | ITGAV (1.00) | ITGAVITGB3ITGB6ITGB1ITGA5 | |
| SCHEMBL20156330 | 0.79 | ITGAV (0.56) | ITGAVITGB3ITGB6ITGB1ITGA5 | |
| SCHEMBL20153378 | 0.79 | ITGAV (0.65) | ITGAVITGB3ITGB6ITGB1ITGA5 | |
| SCHEMBL21294579 | 0.78 | ITGAV (0.71) | ITGAVITGB3ITGB6ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089353-A1 | 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |