Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10725927 | 0.77 | GAA (0.35) | GAALMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL12824669 | 0.74 | LMNA (0.41) | GAALMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8422238 | 0.74 | LMNA (0.41) | GAALMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL14771635 | 0.74 | LMNA (0.41) | GAALMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL25726608 | 0.73 | ACACB (0.38) | — | |
| Pidolic Acid SCHEMBL4640508 | 0.71 | CAD (0.42) | GAALMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6664539 | 0.70 | — | — | |
| SCHEMBL14827812 | 0.70 | — | — | |
| SCHEMBL23470353 | 0.69 | SMN1; SMN2 (0.36) | GAALMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL9473779 | 0.68 | HSD17B10 (0.42) | GAALMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089402-A1 | TRICYCLIC SULFONES AS ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |