Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELOVL6 | Q9H5J4 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20160526 | 0.88 | ELOVL6 (0.49) | ELOVL6MAPTGRIN2BSMN1; SMN2PAX8 | |
| SCHEMBL20153135 | 0.85 | MAPT (0.56) | ELOVL6MAPTGRIN2BSMN1; SMN2PAX8 | |
| SCHEMBL23126197 | 0.84 | MAPT (0.55) | ELOVL6MAPTGRIN2BSMN1; SMN2PAX8 | |
| SCHEMBL23555221 | 0.84 | ALDH1A1 (0.52) | ELOVL6GRIN2BSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL20069825 | 0.82 | KDM4E (0.48) | MAPTSMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL21158715 | 0.82 | ELOVL6 (0.53) | ELOVL6MAPTGRIN2BSMN1; SMN2PAX8 | |
| SCHEMBL23126196 | 0.74 | ALDH1A1 (0.50) | ELOVL6GRIN2BSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL1574353 | 0.73 | MAPT (0.61) | MAPTGRIN2BSMN1; SMN2PAX8BLM | |
| SCHEMBL16178389 | 0.73 | MAPT (0.61) | ELOVL6MAPTGRIN2BSMN1; SMN2PAX8 | |
| SCHEMBL22030762 | 0.72 | RET (0.47) | MAPTSMN1; SMN2RAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10172851-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180133213-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10172851-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, ROR1, BRAF | ELOVL6 4837/4885MAPT 1769/4885GRIN2B 996/4885 |
| US-20180133213-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | ELOVL6 4837/4885MAPT 1769/4885GRIN2B 996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.