Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | AOC1 | P19801 | 3/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.38 |
| ▸ | CDK2 | P24941 | 7/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCND2 | P30279 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19359631 | 1.00 | PAK1 (0.39) | PAK1AOC1AOC3CCNA2CDK2 | |
| SCHEMBL19359626 | 0.82 | CCNA2 (0.42) | CCNA2CDK2CCNA1AURKAHDAC3 | |
| SCHEMBL22313896 | 0.81 | CCNA2 (0.38) | CCNA2CDK2CCNA1AURKAHDAC3 | |
| SCHEMBL20155195 | 0.79 | CTSK (0.45) | PAK1CCNA2CDK2CCNA1KDM4E | |
| SCHEMBL19359660 | 0.79 | CTSK (0.45) | PAK1CCNA2CDK2CCNA1KDM4E | |
| SCHEMBL20155196 | 0.78 | CCNA2 (0.41) | CCNA2CDK2CCNA1AURKAADORA1 | |
| SCHEMBL19359629 | 0.74 | AOC1 (0.48) | PAK1AOC1AOC3CCNA2CDK2 | |
| SCHEMBL19359654 | 0.74 | AOC1 (0.48) | PAK1AOC1AOC3CCNA2CDK2 | |
| SCHEMBL22313395 | 0.74 | AOC1 (0.48) | PAK1AOC1AOC3CCNA2CDK2 | |
| SCHEMBL12330009 | 0.66 | CCNA2 (0.48) | PAK1CCNA2CDK2CCNA1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10414770-B2 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2019-09-17 | — | — | US | disclosed |
| US-20180134716-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | MILLENNIUM PHARMACEUTICALS, INC. | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10414770-B2 | Compounds and methods for inhibiting mitotic progression | AURKC, AURKA, AURKB | PAK1 548/4885AOC1 3669/4885AOC3 4120/4885 |
| US-20180134716-A1 | COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | AURKC, AURKA, AURKB | PAK1 548/4885AOC1 3669/4885AOC3 4120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.