Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.39 |
| ▸ | RET | P07949 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 11/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20155151 | 0.83 | — | — | |
| SCHEMBL20155435 | 0.83 | KDR (0.35) | KDRFLT3 | |
| SCHEMBL28316496 | 0.77 | EGFR (0.31) | EGFRERBB2RET | |
| SCHEMBL20155721 | 0.77 | EGFR (0.31) | EGFRERBB2RET | |
| SCHEMBL20155142 | 0.77 | CREBBP (0.32) | — | |
| SCHEMBL20155576 | 0.75 | RET (0.42) | EGFRERBB2RETKDR | |
| SCHEMBL12303702 | 0.75 | RET (0.52) | EGFRERBB2RETKDRFLT3 | |
| SCHEMBL2452602 | 0.75 | RET (0.52) | EGFRERBB2RETKDRFLT3 | |
| SCHEMBL28480333 | 0.74 | RET (0.41) | EGFRERBB2RETKDRFLT3 | |
| SCHEMBL6734377 | 0.72 | ALDH1A1 (0.42) | EGFRERBB2RETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086604-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATIONS THEREOF | 山东罗欣药业集团股份有限公司 | 2018-05-17 | — | — | WO | disclosed |