Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | ICMT | O60725 | 6/20 | 0.35 |
| ▸ | DHFR | P00374 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 3/20 | 0.34 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL2022550 | 0.86 | SCNN1A (0.34) | — | |
| Iodide SCHEMBL2017398 | 0.85 | ADORA2A (0.36) | — | |
| Iodide SCHEMBL2024368 | 0.85 | ALDH1A1 (0.36) | — | |
| SCHEMBL12636337 | 0.84 | ADORA2A (0.37) | — | |
| SCHEMBL2016440 | 0.84 | ALDH1A1 (0.37) | — | |
| Iodide SCHEMBL2014693 | 0.82 | SCNN1A (0.37) | — | |
| Iodide SCHEMBL2053125 | 0.81 | DRD5 (0.38) | TSPOICMTABL1CHRNA7 | |
| Iodide SCHEMBL2022260 | 0.81 | SCNN1A (0.38) | — | |
| Iodide SCHEMBL2018595 | 0.79 | DRD5 (0.39) | — | |
| Iodide SCHEMBL2019947 | 0.78 | DRD5 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | claimed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |