Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | PTGIR | P43119 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21281611 | 0.78 | KMT2A (0.44) | ALDH1A1MAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL23400397 | 0.76 | ALDH1A1 (0.57) | ALDH1A1KDM4EMAPTL3MBTL1MEN1 | |
| SCHEMBL23399527 | 0.75 | KMT2A (0.43) | ALDH1A1KDM4EMAPTL3MBTL1MEN1 | |
| SCHEMBL23400421 | 0.73 | RECQL (0.41) | ALDH1A1KDM4EMAPTL3MBTL1MEN1 | |
| SCHEMBL23400987 | 0.73 | AURKA (0.37) | ALDH1A1KDM4EMAPTL3MBTL1MEN1 | |
| SCHEMBL23402101 | 0.71 | PTGIR (0.44) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL23403188 | 0.70 | ADORA3 (0.43) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL23399568 | 0.70 | KMT2A (0.58) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL23398902 | 0.70 | S1PR1 (0.45) | ALDH1A1KDM4EMEN1KMT2APTGIR | |
| SCHEMBL15135221 | 0.66 | MEN1 (0.50) | ALDH1A1KDM4EMAPTL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089358-A1 | AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |