Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 14/20 | 0.44 |
| ▸ | ITGB6 | P18564 | 9/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 6/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156055 | 0.88 | ITGAV (0.47) | ITGAVITGB6CXCR4ITGB3 | |
| SCHEMBL20156054 | 0.88 | ITGAV (0.47) | ITGAVITGB6CXCR4ITGB3 | |
| SCHEMBL20156298 | 0.84 | ITGAV (0.57) | ITGAVITGB6CXCR4ITGB3 | |
| SCHEMBL19825653 | 0.79 | ITGAV (0.62) | ITGAVITGB6ITGB3 | |
| SCHEMBL18104630 | 0.79 | ITGAV (0.62) | ITGAVITGB6ITGB3 | |
| SCHEMBL20156094 | 0.79 | ITGAV (0.49) | ITGAVITGB6CXCR4ITGB3 | |
| SCHEMBL20156009 | 0.78 | CXCR4 (0.47) | ITGAVITGB6CXCR4ITGB3 | |
| SCHEMBL20156008 | 0.78 | ITGAV (0.53) | ITGAVITGB6CXCR4ITGB3 | |
| SCHEMBL20156096 | 0.77 | ITGAV (0.67) | ITGAVITGB6ITGB3 | |
| SCHEMBL23912887 | 0.76 | ITGAV (0.48) | ITGAVITGB6CXCR4ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538527-B1 | AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-10-13 | — | — | EP | disclosed |
| WO-2018089358-A1 | AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |