Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.57 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013812 | 0.91 | HCRTR1 (0.59) | HCRTR1HCRTR2NPC1RAB9AALDH1A1 | |
| SCHEMBL2012866 | 0.90 | HCRTR1 (0.59) | HCRTR1HCRTR2NPC1RAB9AGSK3B | |
| SCHEMBL2012867 | 0.90 | HCRTR1 (0.59) | HCRTR1HCRTR2NPC1RAB9AGSK3B | |
| SCHEMBL2015645 | 0.84 | HCRTR1 (0.59) | HCRTR1HCRTR2NPC1RAB9AHDAC1 | |
| SCHEMBL2052696 | 0.84 | HCRTR1 (0.59) | HCRTR1HCRTR2NPC1RAB9AHDAC1 | |
| SCHEMBL13139093 | 0.81 | HCRTR1 (0.77) | HCRTR1HCRTR2NPC1RAB9AHDAC3 | |
| SCHEMBL13139102 | 0.81 | HCRTR1 (0.71) | HCRTR1HCRTR2NPC1RAB9AHDAC3 | |
| SCHEMBL2012839 | 0.81 | HCRTR1 (0.59) | HCRTR1HCRTR2NPC1RAB9AALDH1A1 | |
| SCHEMBL2012204 | 0.80 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13139060 | 0.80 | HCRTR1 (0.77) | HCRTR1HCRTR2NPC1RAB9AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |