SCHEMBL20156673

SCHEMBL20156673

O=C(O)Oc1cc(F)c(F)c(F)c1F

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CES2 O00748 4/20 0.38
CES1 P23141 4/20 0.38
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
CA4 P22748 2/20 0.35
LMNA P02545 1/20 0.32
MAPK1 P28482 1/20 0.32
HTT P42858 1/20 0.32
RAB9A P51151 1/20 0.32
POLB P06746 1/20 0.32
POLA1 P09884 1/20 0.32
ANTXR2 P58335 1/20 0.32
INPPL1 O15357 1/20 0.31
SLC2A1 P11166 1/20 0.30
SLC2A4 P14672 1/20 0.30
CYP4F2 P78329 1/20 0.30
CYP4A11 Q02928 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL474387 0.84 CES2 (0.39) CES2CES1CA1CA2CA4
SCHEMBL5588963 0.83 POLB (0.42) CES2CES1CA1CA2CA4
SCHEMBL15454206 0.82 CES2 (0.34) CES2CES1CA1CA2CA4
SCHEMBL31006941 0.81 CYP4F2 (0.47) CES2CES1LMNAHTTRAB9A
SCHEMBL823844 0.81 CYP4F2 (0.47) CES2CES1LMNAHTTRAB9A
SCHEMBL31613088 0.81 MEN1 (0.38) CES2CES1CA1CA2CA4
SCHEMBL10180097 0.79 KMT2A (0.53) LMNASLC2A1SLC2A4
SCHEMBL3827377 0.78 CES2 (0.45) CES2CES1LMNAMAPK1HTT
SCHEMBL10180065 0.78 CES2 (0.34) CES2CES1CA1CA2CA4
SCHEMBL29319716 0.78 CES2 (0.34) CES2CES1CA1CA2CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3538510-B1 PROCESS FOR THE PREPARATION OF MONO-PROTECTED ALPHA,OMEGA-DIAMINO ALKANES BYONDIS BV (NL) 2021-01-06 EP disclosed
WO-2018086993-A1 PROCESS FOR THE PREPARATION OF MONO-PROTECTED alpha,omega-DIAMINO ALKANES SYNTHON BIOPHARMACEUTICALS B.V. (NL) 2018-05-17 WO disclosed