Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG2 | P78540 | 9/20 | 0.52 |
| ▸ | ARG1 | P05089 | 8/20 | 0.52 |
| ▸ | FDPS | P14324 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.44 |
| ▸ | ODC1 | P11926 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3450922 | 0.98 | ARG2 (0.50) | ARG2ARG1FDPSMEN1ALDH1A1 | |
| SCHEMBL31678259 | 0.98 | ARG2 (0.50) | ARG2ARG1FDPSMEN1ALDH1A1 | |
| SCHEMBL7087301 | 0.96 | ARG2 (0.55) | ARG2ARG1FDPSMEN1ALDH1A1 | |
| SCHEMBL6129347 | 0.93 | ARG2 (0.53) | ARG2ARG1FDPSMEN1ALDH1A1 | |
| SCHEMBL14088071 | 0.93 | ARG2 (0.53) | ARG2ARG1FDPSMEN1ALDH1A1 | |
| SCHEMBL23010905 | 0.93 | ARG1 (0.48) | ARG2ARG1FDPSMEN1ALDH1A1 | |
| SCHEMBL3024369 | 0.93 | ARG2 (0.53) | ARG2ARG1FDPSMEN1ALDH1A1 | |
| SCHEMBL21219814 | 0.93 | ARG2 (0.53) | ARG2ARG1FDPSMEN1ALDH1A1 | |
| SCHEMBL8719171 | 0.93 | ARG2 (0.53) | ARG2ARG1FDPSMEN1ALDH1A1 | |
| SCHEMBL11421459 | 0.93 | ARG2 (0.53) | ARG2ARG1FDPSMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089490-A1 | ARGINASE INHIBITOR COMBINATION THERAPIES | CALITHERA BIOSCIENCES, INC. (US) | 2018-05-17 | — | — | WO | disclosed |