Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 2/20 | 0.45 |
| ▸ | ARG2 | P78540 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 4/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | BCL2 | P10415 | 3/20 | 0.34 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL894766 | 0.90 | ARG1 (0.60) | ARG1ARG2 | |
| SCHEMBL30169903 | 0.90 | ARG1 (0.60) | ARG1ARG2 | |
| Hydrochloric Acid SCHEMBL894753 | 0.89 | ARG1 (0.59) | ARG1ARG2 | |
| SCHEMBL20683436 | 0.81 | ARG1 (0.46) | ARG1ARG2OPRM1OPRD1OPRK1 | |
| SCHEMBL895122 | 0.80 | ARG2 (0.61) | ARG1ARG2 | |
| SCHEMBL30170003 | 0.80 | ARG2 (0.61) | ARG1ARG2 | |
| SCHEMBL10265625 | 0.80 | ARG1 (0.46) | ARG1ARG2OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL895078 | 0.80 | ARG1 (0.60) | ARG1ARG2 | |
| SCHEMBL895121 | 0.78 | ARG2 (0.63) | ARG1ARG2 | |
| SCHEMBL30169798 | 0.78 | ARG2 (0.63) | ARG1ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089490-A1 | ARGINASE INHIBITOR COMBINATION THERAPIES | CALITHERA BIOSCIENCES, INC. (US) | 2018-05-17 | — | — | WO | disclosed |