Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 10/20 | 0.56 |
| ▸ | ARG2 | P78540 | 10/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL894722 | 0.90 | ARG1 (0.71) | ARG1ARG2HTT | |
| SCHEMBL30169899 | 0.90 | ARG1 (0.71) | ARG1ARG2HTT | |
| Hydrochloric Acid SCHEMBL894467 | 0.89 | ARG1 (0.70) | ARG1ARG2HTT | |
| SCHEMBL16309661 | 0.83 | ARG1 (0.77) | ARG1ARG2TSHRKMT2AMEN1 | |
| SCHEMBL19055967 | 0.83 | ARG1 (0.77) | ARG1ARG2TSHRKMT2AMEN1 | |
| SCHEMBL10265155 | 0.83 | ARG1 (0.77) | ARG1ARG2TSHRKMT2AMEN1 | |
| SCHEMBL20683407 | 0.77 | ARG1 (0.60) | ARG1ARG2HTTALDH1A1 | |
| SCHEMBL19576669 | 0.77 | ARG1 (0.80) | ARG1ARG2KMT2AMEN1ALDH1A1 | |
| SCHEMBL20683471 | 0.77 | ARG1 (0.67) | ARG1ARG2ABL1RIN1GRM2 | |
| SCHEMBL20683399 | 0.75 | ARG1 (0.67) | ARG1ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089490-A1 | ARGINASE INHIBITOR COMBINATION THERAPIES | CALITHERA BIOSCIENCES, INC. (US) | 2018-05-17 | — | — | WO | disclosed |