Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 12/20 | 0.60 |
| ▸ | ARG2 | P78540 | 12/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20683399 | 0.91 | ARG1 (0.67) | ARG1ARG2SIGMAR1 | |
| SCHEMBL20683512 | 0.90 | ARG1 (0.53) | ARG1ARG2SIGMAR1 | |
| SCHEMBL894278 | 0.89 | ARG1 (0.78) | ARG1ARG2SIGMAR1ALDH1A1 | |
| SCHEMBL19576669 | 0.85 | ARG1 (0.80) | ARG1ARG2SIGMAR1ALDH1A1 | |
| SCHEMBL10265155 | 0.84 | ARG1 (0.77) | ARG1ARG2SIGMAR1 | |
| SCHEMBL16309661 | 0.84 | ARG1 (0.77) | ARG1ARG2SIGMAR1 | |
| SCHEMBL19055967 | 0.84 | ARG1 (0.77) | ARG1ARG2SIGMAR1 | |
| SCHEMBL18323829 | 0.83 | ARG1 (0.80) | ARG1ARG2SIGMAR1 | |
| SCHEMBL20683403 | 0.82 | ARG1 (0.56) | ARG1ARG2SIGMAR1 | |
| SCHEMBL20156713 | 0.82 | ARG1 (0.74) | ARG1ARG2SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560978-B1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS INC (US) | 2019-01-30 | — | — | EP | disclosed |