Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.48 |
| ▸ | RPTOR | Q8N122 | 7/20 | 0.48 |
| ▸ | MLST8 | Q9BVC4 | 7/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140779 | 0.88 | GRM1 (0.42) | MTORRPTORMLST8DRD4MEN1 | |
| SCHEMBL20140827 | 0.82 | MTOR (0.51) | MTORRPTORMLST8GFERCTDSP1 | |
| SCHEMBL20140558 | 0.81 | MTOR (0.51) | MTORRPTORMLST8NAMPTTACR3 | |
| SCHEMBL20141890 | 0.81 | MTOR (0.51) | MTORRPTORMLST8NAMPTTACR3 | |
| SCHEMBL20141841 | 0.81 | DRD4 (0.41) | MTORRPTORMLST8DRD4PHGDH | |
| SCHEMBL22187868 | 0.80 | MTOR (0.57) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL21360359 | 0.80 | MTOR (0.71) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20142669 | 0.80 | MTOR (0.50) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20133543 | 0.80 | MTOR (0.62) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20142672 | 0.80 | MTOR (0.50) | MTORRPTORMLST8CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |