Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 5/20 | 0.41 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.41 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.41 |
| ▸ | NAAA | Q02083 | 10/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156844 | 0.88 | MTOR (0.48) | MTORRPTORMLST8DRD4MEN1 | |
| SCHEMBL20142672 | 0.86 | MTOR (0.50) | GRM1MTORRPTORMLST8NAAA | |
| SCHEMBL20142669 | 0.86 | MTOR (0.50) | GRM1MTORRPTORMLST8NAAA | |
| SCHEMBL20140280 | 0.84 | GRM1 (0.45) | GRM1MTORRPTORMLST8NAAA | |
| SCHEMBL20142818 | 0.84 | GRM1 (0.45) | GRM1MTORRPTORMLST8NAAA | |
| SCHEMBL20140914 | 0.83 | MTOR (0.47) | GRM1MTORRPTORMLST8DRD4 | |
| SCHEMBL20140416 | 0.81 | GRM1 (0.43) | GRM1MTORRPTORMLST8NAAA | |
| SCHEMBL20140821 | 0.81 | MTOR (0.45) | GRM1MTORRPTORMLST8HCRTR1 | |
| SCHEMBL20140823 | 0.81 | MTOR (0.45) | GRM1MTORRPTORMLST8HCRTR1 | |
| SCHEMBL20140709 | 0.77 | GRM1 (0.50) | GRM1MTORRPTORMLST8NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |